Case Study – Ontario Group of Hospitals

Ontario-based hospitals use a custom Hereditary Cancer Solution by SOPHiA GENETiCS™ for Provincial Hereditary Cancer Testing



Research Challenge

Custom future-proof gene list, cost and time effective workflow


In Ontario, Canada, eligibility criteria for hereditary cancer testing has previously been limited to breast and ovarian cancer, Lynch syndrome and polyposis. In 2021, Provincial Hereditary Cancer Testing was implemented to expand the eligibility criteria and increase clinically appropriate access to cancer genetic testing in the region1. Two community laboratories required an expanded hereditary cancer testing solution that would enable them to:
  • Fulfil the updated Ontario guidelines
  • Keep testing in-house
  • Utilize a user-friendly secondary and tertiary analysis platform
  • Maximize efficiency of their laboratory workflows

Both hospitals required an optimal solution that could effectively meet their needs, as well as those of the local governing body. The teams were aware of the financial, logistical, and technical challenges associated with adopting a custom panel.

1. Ontario Health. Cancer Care Ontario. Hereditary Cancer Testing Eligibility Criteria: Version 3. 1 October 2022.

Disclaimer: The SOPHiA DDM™ Comprehensive Hereditary Cancer Solution is for Research Use Only and not for use in diagnostic procedures. The information in this presentation is about a product that may or may not be available in different countries and, if applicable, may or may not have received approval or market clearance by a governmental regulatory body for different indications for use. Please contact [email protected] to obtain the appropriate product information for your country of residence. SOPHIA GENETICS™ does not accept any liability for products, for clinical, diagnostic or other use that have been self-validated by third parties.

Learn more about how these Ontario-based Hospitals adopted a customized SOPHiA DDM™ Comprehensive Hereditary Cancer solution for their Laboratories.

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