SOPHiA DDM™ for Genomics

Data in, answers out.

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Discover the full power of your genomic data

Next-generation sequencing (NGS) has the potential to revolutionize the diagnosis and treatment of cancers and rare diseases but creates extremely large, complex, and noisy datasets for analysis. Without the right analytical technology, pinpointing causative variants and obtaining actionable insights from NGS data requires specialist skills, multiple resources, and considerable time.

The SOPHiA DDM™ Platform uses machine learning with patented algorithms to efficiently call, annotate, and pre-classify variants from raw NGS data. User-friendly features streamline prioritization, simplify interpretation, and expedite reporting.

Spot causative variants with confidence

Quickly find answers from complex and noisy NGS data sets and make data-driven decisions with the SOPHiA DDM™ Platform. High-throughput genomic analysis is possible in any laboratory, with end-to-end workflows tailored to your experimental setting.

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From data to insights in 5 steps

1. Login and data upload

Secure login with 2-step verification

Quick upload of FASTQ files

Performance pipelines tailored to sample type, chemistry, enrichment kit, and sequencer

2. Variant calling and annotation

Somatic and germline pipelines, optimized for targeted to exome-sized applications

Single- or multi-sample (trio) analysis

Advanced accuracy across multiple variant types in a single experiment

Detailed quality metrics

No bioinformatics expertise needed

Comprehensive annotation with up-to-date information from >55 world-renowned curated databases, guidelines, and predictors

3. Prioritization and filtering

User-friendly interface

Variant pathogenicity levels assigned using machine learning complemented by guideline-driven ranking

Multiple filtering functionalities to focus on disease-specific variants, create custom filtering strategies, and/or filter by inheritance mode

4. Exploration and Interpretation

Integrated features contextualize variants

OncoPortal™ Plus for Oncology – Molecular profiles are matched to therapeutic, diagnostic, and prognostic clinical associations

Alamut™ Visual Plus for Rare and Inherited Diseases – Variants are visualized in a comprehensive full genome browser

SOPHiA GENETICS Community insights further support variant exploration

5. Reporting

User-driven templates for customization

CAP- and CLIA-compliant

User friendly

Guideline-driven information for decision making

SOPHiA DDM™️ in Action

Watch how the SOPHiA DDM™️ Platform streamlines end-to-end workflows during this 3-minute tutorial video that walks through the key steps of homologous recombination deficiency (HRD) analysis.

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Join the SOPHiA GENETICS™ Community to share knowledge with your peers and confidently interpret variants. The SOPHiA GENETICS™ Community is one of the largest networks of healthcare institutions, where experts can indicate variant pathogenicity levels with the flagging feature, greatly facilitating interpretation, even of variants of unknown significance.

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Secure and private

Trusted cloud capabilities offer robust and unmatched data security compliance for the utmost peace of mind.

ISO 27001 certified

GDPR and HIPAA compliant

Adapts to local laws

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Learn more

SOPHiA DDM™ for Oncology

Easily manage and efficiently explore your genomic data to characterize and report relevant alterations associated with solid tumors and hematological malignancies.

SOPHiA DDM™ For Blood Cancers

SOPHiA DDM™ for Rare and Inherited Diseases

Quickly and accurately analyze the massive amount of data coming from your NGS-based applications (from targeted panels to whole exomes) to identify variants associated with rare and inherited diseases.

SOPHiA DDM™ For Blood Cancers

Delivering deep, impactful insights to BioPharma

Leverage our broad real-world genomic database and AI-driven analytics to support your clinical development strategy and:

  • gain insights into biomarker testing practices
  • streamline biomarker-driven clinical trial enrollment
  • accelerate drug development process
A universal health data analytics platform for a decentralized approach to healthcare
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Want to know more?
Get in touch with us.

Our client services team is on hand to help.