Technical Note: Measuring ctDNA fraction with SOPHiA DDM™

Published on 08/10/26
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Explore how MSK-ACCESS® powered with SOPHiA DDM™ measures circulating tumor DNA (ctDNA) fraction for improved interpretation of liquid biopsy results.
Home breadcrumb-arrow Technical Note: Measuring ctDNA fraction with SOPHiA DDM™
Explore how MSK-ACCESS® powered with SOPHiA DDM™ measures circulating tumor DNA (ctDNA) fraction for improved interpretation of liquid biopsy results.

This Technical Note explores why circulating tumor DNA (ctDNA) fraction is a key interpretive parameter in liquid biopsy analysis, from interpreting negative results to supporting treatment response assessment and resistance evolution research.

We highlight how MSK-ACCESS® powered with SOPHiA DDM™ uses a matched tumor-normal approach and the SESAME AI agent for robust ctDNA estimation within one fully integrated workflow. Learn how ctDNA fraction adds context to the interpretation of variants and complex biomarkers, including microsatellite instability (MSI).

MSK-ACCESS® powered with SOPHiA DDM™ is for Research Use Only (RUO). RUO results must not be used for clinical diagnosis or patient management.

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