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SOPHiA DDM™ for
SARS-CoV-2

Accelerate Covid-19 research and surveillance

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The SOPHiA GENETICS SARS-CoV-2 analytical solutions enable rapid and precise identification of circulating and emerging variants, including Omicron.

Leveraging our extensive experience and knowledge in genomics, the SOPHiA DDM™ platform offers analysis of the whole viral genome for sensitive variant detection through streamlined, end-to-end bioinformatics workflows (including as early as sampling to surveillance reporting). These solutions accelerate surveillance and evolution studies of SARS-CoV-2.

SARS-CoV-2 solutions offer future-proof strain identification including*:
‘Omicron’ (B.1.1.529), ‘Alpha’ (B.1.1.7), ‘Beta’ (B.1.351), ‘Gamma’ (P.1), ‘Epsilon’ (B.1.429), ‘Iota’ (B.1.526), ‘Kappa’ (B.1.617), ‘Mu’ (B.1.621)

Fast, ultra-sensitive SARS-CoV-2 whole genome analysis with tailored quality assessment

Featuring Omicron variant detection: optimized identification and filtering for current and emerging variants

Integrated access to public databases and secure knowledge sharing through SOPHiA DDM™ community networks
SARS-CoV-2 Surveillance Reporting for real-time insights from SARS-CoV-2 data
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Product Details

Identify new and emerging variants with confidence

SOPHiA GENETICS SARS-CoV-2 solutions are fast, highly sensitive and analytically accurate to surveil circulating, emerging variants on a global scale. The overall clade distribution in the SOPHiA DDM™ platform is similar to results from global datasets which require manual analysis and interpretation. Using the SOPHiA DDM™ platform, data quality is controlled, analyses can be automated, and data is screened in real time.

SARS-CoV2 Data
The top graph shows trends of emerging circulating variants collected from nearly 10,000 viral profiles across SOPHiA GENETICS’ decentralized SARS-CoV-2 community of 71 institutions in 15 countries. The graph shows that SOPHiA DDM™ reflects the global dynamics found in NextStrain’s public database [Hadfield et al., Nextstrain: real-time tracking of pathogen evolution, Bioinformatics (2018)].
Flyer Mockup COVID report

Real-time reporting of SARS-CoV-2 data with the SOPHiA GENETICS SARS-CoV-2 Surveillance Report

The SOPHiA DDM™ platform provides at-a-glance reporting to streamline the interpretation process for variants of concern (VOC), including valuable insights such as:

  • Lineages associated with spike mutations
  • Variant classification (VOC, VOI/VUI, VOHC, Monitoring) consistent with WHO/CDC and Public Health England
  • Real-time tracking of known circulating variants by geography
  • Hotspot identification by variant
  • Key spike protein mutational monitoring
  • New mutation and new mutation combination spotlights
  • Insights enhanced with published scholarly data
sars-cov-2 workflow
*Results may vary. Data on file with Paragon CleanPlex® SARS-CoV-2 FLEX.
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Available SARS-Cov-2 Panels

The SOPHiA DDM™ platform pairs with highly multiplexed target enrichment panels to generate high-quality NGS libraries, reaching up to 99% coverage of the viral genome for more robust and confident variant calling (even during viral mutation).
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Feature / Application Paragon Genomics Cleanplex® Paragon Genomics Flex® QIAseq®
SARS-CoV-2		 ARTICv3®
SARS-CoV-2​		 ATOPlex®
SARS-CoV-2 V1
SARS-CoV-2 Detection ✓ ✓ ✓ ✓ ✓
Surveillance and Monitoring ✓ ✓ ✓ ✓ ✓
Variant Typing ✓ ✓ ✓ ✓ ✓
New Variant Research ✓ ✓ ✓ ✓ ✓
Library Preparation Kits Available ✓ ✓ – – –
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