Going beyond HRR mutations: A deep-learning approach on HRD detection in ovarian cancer

Going beyond HRR mutations: A deep-learning approach on HRD detection in ovarian cancer

 Homologous recombination deficiency (HRD) is an important prognostic and predictive biomarker in ovarian cancer. It is assessed by combining information from homologous recombination repair (HRR) gene mutations, the “cause” of HRD, with a measure of genomic scarring, the “effect” of HRD. However, implementing HRD analysis in-house can be challenging due to technical limitations, such as the requirement for deep genomic profiling data. Deep learning-based approaches that leverage low-pass whole genome sequencing (WGS) can help overcome limitations and maximize insights from raw NGS data for accurate in-house HRD detection.

In this webinar, Dr. Nicola Normanno (Director, Translational Research, National Cancer Institute, Italy Pascale Foundation) presents analytical performance results from an in-house evaluation of HRD status in ovarian cancer samples using the deep learning-based SOPHiA DDM™ HRD Solution.

SOPHiA DDM™ HRD Solution is for research use only, not for use in diagnostic procedures.

 

 

 

 

 

 

Event Date
January 19, 2024 –

Event Type

Webinar

Event Location

Europe

Areas of Interest

Platform

Disclaimer notice:

The term SOPHIA used by the speaker refers to SOPHiA GENETICS and its products.

The opinions expresseda during this presentation are these of the speaker and may not represent the opinions of SOPHiA GENETICS.

SOPHiA GENETICS does not provide support in the validation of custom products for clinical use.

SOPHiA GENETICS products are for Research Use Only and not for use in diagnostic procedures unless specified otherwise. Information about products that may or may not be available in different countries and if applicable, may or may not have received approval or market clearance by a governmental regulatory body for different indications for use. Please contact us at [email protected] to obtain the appropriate product information for your country of residence.

pink dots icon

Want to know more?
Get in touch with us.

Our client services team is on hand to help.
';