SOPHiA Lymphoma Solution

The proven path to characterize lymphoma
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SOPHiA Lymphoma Solution is a ready-to-use genomic application, designed to empower clinical researchers to make better-informed decisions in the assessment of different lymphoma types.


The application combines a capture-based target enrichment kit with the advanced analytical capabilities of the SOPHiA DDM™ platform providing high-quality and reproducible data through a streamlined workflow from sample to report.

This comprehensive solution accurately covers 54 genes associated with B- and T-cell lymphomas such as diffuse large B-cell, follicular, mantle cell and Burkitt lymphoma. Through a streamlined, customizable, and scalable NGS-based workflow, SOPHiA Lymphoma Solution reduces turnaround time and improves the efficiency of assessing complex variants associated with lymphomas.

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Highlights

  • Ready-to-use target enriched library in just 1.5 days
  • Compatible with blood and FFPE samples
  • Data analysis from FASTQ files from 4 hours
  • Uniform coverage of DNA alterations (e.g., CREBBP, EP300, EZH2, MEF2B, MYD88, MYC, BRAF) aligned with recent guidelines
  • Accurate detection and annotation of challenging variants, including SNVs, Indels and gene amplifications
  • Streamlined interpretation with the SOPHiA DDM™ intuitive variant filters, algorithm-supported variant classification, and access to:
  • OncoPortal™ to obtain the latest scientific evidence on all detected variants
  • One of the largest networks of connected healthcare institutions to gain and share knowledge on relevant variants
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Specifications

Parameters Lymphoma Solution
Addressed Diseases B- and T-cell lymphomas such as diffuse large B-cell, follicular, mantle cell, and Burkitt lymphomas
Covered Genes 54 genes with complete coding sequences. Panel: ARID1A, B2M, BCL2, CCND3, CD58, CHD2, CDKN2A, CDKN2B, CIITA, CXCR4, EP300, FOXO1, GNA13, ID3, IRF4, KMT2A, KMT2D, MAL, MEF2B, MYC, MYD88, NFKBIE, PAX5, PIM1, POT1, PRDM1, PTPN11, REL, SOCS1, TNFAIP3, TNFRSF14, TP53, ATM, BCL6, BIRC, BRAF, BTK, CARD11, CCND1, CD79A, CD79B, CREBBP, EZH2, FBXW7, KRAS, NOTCH1, NOTCH2, NRAS), PLCG2, PTEN, SF3B1, STAT6, TCF3, XPO1
Key Biomarkers CREBBP, EP300, EZH2, MEF2B, MYD88, MYC, BRAF
Starting Material 50 ng DNA
Sample Type FFPE, blood, and bone marrow
Sequencer Compatibility
  • Illumina MiSeq® v3
  • Illumina MiSeq® v2
  • Illumina NextSeq® 500/550 Mid Output
  • Illumina NextSeq® 500/550 High Output
Total Library Preparation Time 1.5 days
Analysis Time from FASTQ From 4 hours
Detected Variants SNVs
Indels
Gene amplifications

Dedicated features to ease variant interpretation

The SOPHiA DDM™ platform features variant filters and prioritization options to streamline the interpretation process and help you greatly reduce turnaround time.

Virtual Panels to limit the interpretation to a subset of genes
Cascading Filters to enable user-created custom filtering strategies for quicker identification of relevant variants
OncoPortal™ to support decisions based on the Jax-CKB™, CAP, ASCO, AMP and other data sources

Data pooling and knowledge sharing
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SOPHiA DDM™ for Hereditary Cancers

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