SOPHiA Lymphoma Solution
SOPHiA Lymphoma Solution is a ready-to-use genomic application, designed to empower clinical researchers to make better-informed decisions in the assessment of different lymphoma types.
The application combines a capture-based target enrichment kit with the advanced analytical capabilities of the SOPHiA DDM™ platform providing high-quality and reproducible data through a streamlined workflow from sample to report.
This comprehensive solution accurately covers 54 genes associated with B- and T-cell lymphomas such as diffuse large B-cell, follicular, mantle cell and Burkitt lymphoma. Through a streamlined, customizable, and scalable NGS-based workflow, SOPHiA Lymphoma Solution reduces turnaround time and improves the efficiency of assessing complex variants associated with lymphomas.
Highlights
- Ready-to-use target enriched library in just 1.5 days
- Compatible with blood and FFPE samples
- Data analysis from FASTQ files from 4 hours
- Uniform coverage of DNA alterations (e.g., CREBBP, EP300, EZH2, MEF2B, MYD88, MYC, BRAF) aligned with recent guidelines
- Accurate detection and annotation of challenging variants, including SNVs, Indels and gene amplifications
- Streamlined interpretation with the SOPHiA DDM™ intuitive variant filters, algorithm-supported variant classification, and access to:
- OncoPortal™ to obtain the latest scientific evidence on all detected variants
- One of the largest networks of connected healthcare institutions to gain and share knowledge on relevant variants
Specifications
| Parameters | Lymphoma Solution |
|---|---|
| Addressed Diseases | B- and T-cell lymphomas such as diffuse large B-cell, follicular, mantle cell, and Burkitt lymphomas |
| Covered Genes | 54 genes with complete coding sequences. Panel: ARID1A, B2M, BCL2, CCND3, CD58, CHD2, CDKN2A, CDKN2B, CIITA, CXCR4, EP300, FOXO1, GNA13, ID3, IRF4, KMT2A, KMT2D, MAL, MEF2B, MYC, MYD88, NFKBIE, PAX5, PIM1, POT1, PRDM1, PTPN11, REL, SOCS1, TNFAIP3, TNFRSF14, TP53, ATM, BCL6, BIRC, BRAF, BTK, CARD11, CCND1, CD79A, CD79B, CREBBP, EZH2, FBXW7, KRAS, NOTCH1, NOTCH2, NRAS), PLCG2, PTEN, SF3B1, STAT6, TCF3, XPO1 |
| Key Biomarkers | CREBBP, EP300, EZH2, MEF2B, MYD88, MYC, BRAF |
| Starting Material | 50 ng DNA |
| Sample Type | FFPE, blood, and bone marrow |
| Sequencer Compatibility |
|
| Total Library Preparation Time | 1.5 days |
| Analysis Time from FASTQ | From 4 hours |
| Detected Variants | SNVs Indels Gene amplifications |
Dedicated features to ease variant interpretation
The SOPHiA DDM™ platform features variant filters and prioritization options to streamline the interpretation process and help you greatly reduce turnaround time.
• Virtual Panels to limit the interpretation to a subset of genes
• Cascading Filters to enable user-created custom filtering strategies for quicker identification of relevant variants
• OncoPortal™ to support decisions based on the Jax-CKB™, CAP, ASCO, AMP and other data sources
Resources
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