SOPHiA Lymphoma Solution
This comprehensive solution accurately covers 54 genes associated with B- and T-cell lymphomas such as diffuse large B-cell, follicular, mantle cell and Burkitt lymphoma. The application combines a capture-based target enrichment kit with the advanced analytical capabilities of the SOPHiA DDM™ platform, providing high-quality and reproducible data through a streamlined workflow from sample to report.
Streamline interpretation with the SOPHiA DDM™ intuitive variant filters, algorithm-supported variant classification with OncoPortal™ to obtain the latest scientific evidence on all the relevant variants
Have access to one of the largest networks of connected healthcare institutions within SOPHiA DDM™, to gain and share knowledge on relevant variants
Product Details
Confidentially asses complex variants associated with cancers of the lymphatic system
This comprehensive solution accurately covers 54 genes associated with B- and T-cell lymphomas such as diffuse large B-cell, follicular, mantle cell and Burkitt lymphoma. Through a streamlined, customizable, and scalable NGS-based workflow, SOPHiA Lymphoma Solution reduces turnaround time and improves the efficiency of assessing complex variants associated with lymphomas.
Dedicated features to ease variant interpretation
The SOPHiA DDM™ platform features intuitive variant filters and prioritization options to streamline the interpretation process and help you greatly reduce turnaround time.
- Virtual Panels to limit the interpretation to a subset of genes
- Cascading Filters to enable user-created custom filtering strategies for quicker identification of relevant variants
- OncoPortal™ to support decisions based on the Jax-CKB™, CAP, ASCO, AMP and other data sources
Specifications
| Parameters | Lymphoma Solution |
|---|---|
| Addressed Diseases | B- and T-cell lymphomas such as diffuse large B-cell, follicular, mantle cell, and Burkitt lymphomas |
| Genes | 54 genes with complete coding sequences. Panel: ARID1A, B2M, BCL2, CCND3, CD58, CHD2, CDKN2A, CDKN2B, CIITA, CXCR4, EP300, FOXO1, GNA13, ID3, IRF4, KMT2A, KMT2D, MAL, MEF2B, MYC, MYD88, NFKBIE, PAX5, PIM1, POT1, PRDM1, PTPN11, REL, SOCS1, TNFAIP3, TNFRSF14, TP53, ATM, BCL6, BIRC, BRAF, BTK, CARD11, CCND1, CD79A, CD79B, CREBBP, EZH2, FBXW7, KRAS, NOTCH1, NOTCH2, NRAS), PLCG2, PTEN, SF3B1, STAT6, TCF3, XPO1 |
| Key Biomarkers | CREBBP, EP300, EZH2, MEF2B, MYD88, MYC, BRAF |
| Starting Material | 50 ng DNA |
| Target Region Size | 118 Kb |
| Sample Type | FFPE, blood, and bone marrow |
| Sequencer Compatibility |
|
| Library Preparation Time | 1.5 days |
| Analysis Time From FASTQ File | From 4 hours |
| Detected Variants |
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