SOPHiA Lymphoma Solution

The proven path to characterize lymphoma
SOPHiA Lymphoma Solution is a ready-to-use genomic application, designed to empower clinical researchers to make better-informed decisions in the assessment of different lymphoma types.

This comprehensive solution accurately covers 54 genes associated with B- and T-cell lymphomas such as diffuse large B-cell, follicular, mantle cell and Burkitt lymphoma. The application combines a capture-based target enrichment kit with the advanced analytical capabilities of the SOPHiA DDM™ platform, providing high-quality and reproducible data through a streamlined workflow from sample to report.​

Ready-to-use target enriched library in just 1.5 days
Compatible with blood and FFPE samples
Data analysis from FASTQ files from 4 hours
Accurate detection and annotation of challenging variants, including SNVs, Indels and gene amplifications

Streamline interpretation with the SOPHiA DDM™ intuitive variant filters, algorithm-supported variant classification with OncoPortal™ to obtain the latest scientific evidence on all the relevant variants

Have access to one of the largest networks of connected healthcare institutions within SOPHiA DDM™, to gain and share knowledge on relevant variants

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    Product Details

    Confidentially asses complex variants associated with cancers of the lymphatic system ​

    This comprehensive solution accurately covers 54 genes associated with B- and T-cell lymphomas such as diffuse large B-cell, follicular, mantle cell and Burkitt lymphoma. Through a streamlined, customizable, and scalable NGS-based workflow, SOPHiA Lymphoma Solution reduces turnaround time and improves the efficiency of assessing complex variants associated with lymphomas.

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    Solid Tumour Shower

    Dedicated features to ease variant interpretation

    The SOPHiA DDM™ platform features intuitive variant filters and prioritization options to streamline the interpretation process and help you greatly reduce turnaround time.

     

    • Virtual Panels to limit the interpretation to a subset of genes
    • Cascading Filters to enable user-created custom filtering strategies for quicker identification of relevant variants
    • OncoPortal™ to support decisions based on the Jax-CKB™, CAP, ASCO, AMP and other data sources
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    Specifications

    Parameters Lymphoma Solution
    Addressed Diseases B- and T-cell lymphomas such as diffuse large B-cell, follicular, mantle cell, and Burkitt lymphomas
    Genes 54 genes with complete coding sequences. Panel: ARID1A, B2M, BCL2, CCND3, CD58, CHD2, CDKN2A, CDKN2B, CIITA, CXCR4, EP300, FOXO1, GNA13, ID3, IRF4, KMT2A, KMT2D, MAL, MEF2B, MYC, MYD88, NFKBIE, PAX5, PIM1, POT1, PRDM1, PTPN11, REL, SOCS1, TNFAIP3, TNFRSF14, TP53, ATM, BCL6, BIRC, BRAF, BTK, CARD11, CCND1, CD79A, CD79B, CREBBP, EZH2, FBXW7, KRAS, NOTCH1, NOTCH2, NRAS), PLCG2, PTEN, SF3B1, STAT6, TCF3, XPO1
    Key Biomarkers CREBBP, EP300, EZH2, MEF2B, MYD88, MYC, BRAF
    Starting Material 50 ng DNA
    Target Region Size 118 Kb
    Sample Type FFPE, blood, and bone marrow
    Sequencer Compatibility
    • Illumina MiSeq® v3
    • Illumina MiSeq® v2
    • Illumina NextSeq® 500/550 Mid Output
    • Illumina NextSeq® 500/550 High Output
    Library Preparation Time 1.5 days
    Analysis Time From FASTQ File From 4 hours
    Detected Variants
    • SNVs
    • Indels
    • Gene amplifications
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