BOSTON, United States and ROLLE, Switzerland, March 3, 2026 — SOPHiA GENETICS (Nasdaq: SOPH), a global leader in AI-driven precision medicine, today reported financial results for the fourth quarter and fiscal year ended December 31, 2025. 

Fourth Quarter 2025 Financial Results 

• Revenue was $21.7 million, up 22% year-over-year 

• Gross margin was 67.7% on a reported basis and 73.9% on an adjusted basis, compared to 68.2% reported and 74.2% adjusted in the prior year period 

• IFRS net loss was $19.2 million, an increase of 27% year-over-year; Adjusted EBITDA loss was $9.9 million, an increase of 9% year-over-year 

Full Year 2025 Financial Results 

• Revenue was $77.3 million, up 19% year-over-year 

• Gross margin was 67.4% on a reported basis and 74.2% on an adjusted basis, compared to 67.4% reported and 72.8% adjusted in the prior year period 

• IFRS net loss was $79.0 million, an increase of 26% year-over-year; Adjusted EBITDA loss was $41.5 million, an increase of 3% year-over-year 

“We finished 2025 strong, with Q4 revenue growing 22% and full-year revenue increasing 19% year-over-year, as our growth momentum continues to accelerate,” said Jurgi Camblong, Chief Executive Officer and co-founder of SOPHiA GENETICS. “We also continued to demonstrate the scalability of our AI-native precision medicine platform, SOPHiA DDM^TM, as adjusted gross margin expanded 140 basis points year-over-year to 74.2% in 2025, even as total terabytes processed by the Platform increased 40% in the same period.” 

Camblong added, “Exceptional new business momentum, including the recent signing of two major integrated health systems in the U.S., which are expected to add 60,000 analyses annually, as well as a record 124 new customers signed in 2025, positions us well for 2026 and beyond. Looking ahead, we expect our primary growth drivers for 2026 to be continued execution in the U.S. market, expansion of our Liquid Biopsy application MSK-ACCESS^® powered with SOPHiA DDM^TM, and renewed momentum in our BioPharma business. We also expect operating leverage to become more pronounced in 2026 as the team and the Platform are now well-positioned to scale with future growth.” 

Business Highlights 

Expanding usage of SOPHiA DDM^TM with existing customers 

• Performed a record 391,000+ analyses in FY 2025, including over 105,000 analyses in Q4 2025 

• Reached 528 core genomics customers as of December 31, 2025, up from 472 customers at the end of 2024 

• Expanded our footprint with existing customers as Net Dollar Retention increased to 115% in 2025, up from 104% in 2024 as customer churn continued to fall 

• Delivered 45% year-over-year analysis growth in North America in Q4 2025 and 32% in Asia Pacific  

Landing new SOPHiA DDM^TM customers to fuel future growth 

• Signed a record 124 new core genomic customers in FY 2025 which will ramp up usage over the next twelve months, up from 92 new customers signed in FY 2024 

• Continued to demonstrate our ability to win larger accounts as the average contract value of new signings was up approximately 120% year-over-year in 2025 

• Signed 30 new customers in Q4 2025, including NYU Langone Health in the United States, AZ Delta system in Belgium, the Human Genome & Stem Cell Research Center in Brazil, and Tyrolpath, one of Austria’s largest pathology labs 

Continued strong business growth in the U.S. market 

• Achieved 50% year-over-year U.S. analysis volume growth in Q4 and 27% growth for FY 2025 

• Signed two of the largest integrated healthcare systems in the U.S. which have committed to using SOPHiA DDM^TM to analyze approximately 60,000 patients annually across the West Coast and Midwest; The accounts are expected to ramp up in the second half of 2026 

• Announced a strategic collaboration with leading U.S. cancer center MD Anderson in Texas to co-develop advanced multimodal oncology testing solutions and accelerate data-driven medicine research 

• Expanded our footprint with existing customers such as Vanderbilt University School of Medicine in Nashville, Memorial Healthcare System in South Florida, and the Icahn School of Medicine at Mount Sinai in New York City, each of which are adopting additional applications 

Accelerating growth with new applications  

• Performed over 7,500 Liquid Biopsy analyses in FY 2025 as customers implement the application and begin to ramp usage 

• Signed over 70 customers to the Liquid Biopsy application MSK-ACCESS^® powered with SOPHiA DDM^TM since its launch, including recent new signings such as the National Institute of Genomic Medicine in Mexico City, the Royal Infirmary of Edinburgh in Scotland, and Vitalité Health Network in Canada 

• Signed a total of 21 customers to the new Solid Tumor applications MSK-IMPACT^® and MSK-IMPACT^® Flex powered with SOPHiA DDM^TM  

Leveraging SOPHiA DDM^TM to deliver value to BioPharma partners 

• Recently signed four contracts with distinct BioPharma partners, reinforcing SOPHiA GENETICS as a trusted leader in AI-driven insights and providing support for 2026 growth 

• Recently agreed to a global commercial agreement with a new top 5 global pharmaceutical company specializing in oncology 

• Continued building on our partnership with Myriad Genetics in the U.S. and A.D.A.M. Innovations in Japan to develop MSK-ACCESS^® powered with SOPHiA DDM^TM into a regulated, global companion diagnostic (CDx) assay, as interest builds amongst BioPharma for this unique, differentiated offering 

Growing sustainably by maintaining an obsession with operational excellence 

• Achieved a 74.2% adjusted gross margin in FY 2025, up 140 basis points year-over-year by continuing to optimize compute costs and leverage the scale of the cloud-native SOPHiA DDM^TM platform 

• Raised $15.5 million in net proceeds from the company’s At-The-Market (ATM) sales program, including $1.1 million raised in Q4 2025 and $14.4 million raised in Q1 2026, executed at a weighted-average price of $5.12 per share; We also expanded our credit facility in January, increasing total available liquidity by $25 million  

• The Company reaffirms commitment to profitable growth and expects to approach adjusted EBITDA breakeven by the end of 2026 and crossing over to positive adjusted EBITDA in the second half of 2027 

2026 Financial Outlook 

Based on information as of today, SOPHiA GENETICS is reaffirming the following guidance:  

• Full-year revenue between $92 million and $94 million, representing approximately 20% to 22% year-over-year growth compared to FY 2025 

• Adjusted EBITDA loss between $29 million and $32 million, compared to $41.5 million in FY 2025  

Earnings Call and Webcast Information 

SOPHiA GENETICS will host a conference call and live webcast to discuss the fourth quarter and full year 2026 results on Tuesday, March 3, 2026, at 8:00 a.m. (08:00) Eastern Time / 2:00 p.m. (14:00) Central European Time. The call will be webcast live on the SOPHiA GENETICS Investor Relations website, ir.sophiagenetics.com. Additionally, an audio replay of the conference call will be available on the SOPHiA GENETICS website after its completion.  

Non-IFRS Financial Measures 

Other than with respect to revenue, the Company only provides guidance on a non-IFRS basis. The Company does not provide a reconciliation of forward-looking adjusted gross margin (non-IFRS measure) to gross margin (the most comparable IFRS financial measure), due to the inherent difficulty in forecasting and quantifying amortization of capitalized research & development expenses that are necessary for such reconciliation. In addition, the Company does not provide a reconciliation of forward-looking adjusted operating loss (non-IFRS measure) to operating loss (the most comparable IFRS financial measure), due to the inherent difficulty in forecasting and quantifying amortization of capitalized research & development expenses and intangible assets, share-based compensation expenses, the non-cash portion of pensions paid in excess of actual contributions, certain transaction costs and litigation expenses that are necessary for such reconciliation. 

To provide investors with additional information regarding the company’s financial results, SOPHiA GENETICS has disclosed here and elsewhere in this earnings release the following non-IFRS measures: 

• Adjusted gross profit, which the company calculates as revenue minus cost of revenue adjusted to exclude amortization of capitalized research and development expenses;  

• Adjusted gross profit margin, which the company calculates as adjusted gross profit as a percentage of revenue;  

• Adjusted operating loss, which the company calculates as operating loss adjusted to exclude amortization of capitalized research and development expenses, amortization of intangible assets, share-based compensation expense, the non-cash portion of pensions expense paid in excess of actual contributions to match the actuarial expense, certain transaction costs and litigation expenses.  

• Adjusted EBITDA, which the company calculates as loss for the period before depreciation, amortization, interest income, interest expense, fair value adjustments on warrant obligations, foreign exchange (losses) gains, net, income tax (expense) benefit, share-based compensation expense, non-cash pension expenses, certain transaction costs and litigation expenses. 

These non-IFRS measures are key measures used by SOPHiA GENETICS management and board of directors to evaluate its operating performance and generate future operating plans. The exclusion of certain expenses facilitates operating performance comparability across reporting periods by removing the effect of non-cash expenses and certain variable charges. Accordingly, the company believes that these non-IFRS measures provide useful information to investors and others in understanding and evaluating its operating results in the same manner as its management and board of directors.  

These non-IFRS measures have limitations as financial measures, and you should not consider them in isolation or as a substitute for analysis of SOPHiA GENETICS’ results as reported under IFRS. Some of these limitations are:  

• These non-IFRS measures exclude the impact of depreciation. Although depreciation is a non-cash charge, the assets being depreciated may need to be replaced in the future and these non-IFRS measures do not reflect capital expenditure requirements for such replacements or for new capital expenditures; 

• These non-IFRS measures exclude the impact of interest expense. Interest expense will continue to be for the foreseeable future a recurring expense based on the company’s financial liabilities; 

• These non-IFRS measures exclude the impact of interest income. Interest income will continue to be for the foreseeable future recurring income based on the company’s financial assets; 

• These non-IFRS measures exclude the impact of income taxes. Income taxes will continue to be for the foreseeable future a recurring expense incurred in the various jurisdictions in which the company operates; 

• These non-IFRS measures exclude the impact of foreign exchange gains (losses),net. Foreign exchange gains and losses will continue to be for the foreseeable future a recurring expense incurred as the company participates in transactions outside of the company’s functional currency; 

• These non-IFRS measures exclude the impact of fair value adjustments of warrant obligations. Fair value adjustments on warrant obligations will continue to be for the foreseeable future a recurring expense incurred as the company has outstanding warrant obligations; 

• These non-IFRS measures exclude the impact of amortization of capitalized research and development expenses and intangible assets. Amortization of these assets will continue to be for the foreseeable future a recurring expense incurred as the Company continues to invest in developing revenue-generating products through research and development. Although amortization is a non-cash charge, the assets being amortized may need to be replaced in the future and these non-IFRS measures do not reflect capital expenditure requirements for such replacements or for new capital expenditures;  

• These non-IFRS measures exclude the impact of share-based compensation expenses. Share-based compensation has been, and will continue to be for the foreseeable future, a recurring expense in the company’s business and an important part of its compensation strategy;  

• These non-IFRS measures exclude the impact of the non-cash portion of pensions paid in excess of actual contributions to match actuarial expenses. Pension expenses have been, and will continue to be for the foreseeable future, a recurring expense in the business;  

• These non-IFRS measures exclude the impact of certain capital markets transaction costs.  These costs may occur from time to time in the future as needed to complete the transactions; 

• These non-IFRS measures exclude the impact of litigation expenses related to the company's defense of lawsuits filed by Guardant Health.  These expenses are expected to continue for the duration of the litigation and may increase in future periods;and 

• Other companies, including companies in the company’s industry, may calculate these non-IFRS measures differently, which reduces their usefulness as comparative measures.   

Because of these limitations, you should consider these non-IFRS measures alongside other financial performance measures, including various cash flow metrics, net income and other IFRS results.  

The tables below provide the reconciliation of the most comparable IFRS measures to the non-IFRS measures for the periods presented.  

Presentation of Constant Currency Revenue 

SOPHiA GENETICS operates internationally, and its revenues are generated primarily in the U.S. dollar, the euro and Swiss franc and, to a lesser extent, British pound, Australian dollar, Brazilian real, Turkish lira and Canadian dollar depending on the company’s customers’ geographic locations. Changes in revenue include the impact of changes in foreign currency exchange rates. We present the non-IFRS financial measure “constant currency revenue” (or similar terms such as constant currency revenue growth) to show changes in revenue without giving effect to period-to-period currency fluctuations. Under IFRS, revenues received in local (non-U.S. dollar) currencies are translated into U.S. dollars at the average monthly exchange rate for the month in which the transaction occurred. When the company uses the term “constant currency”, it means that it has translated local currency revenues for the current reporting period into U.S. dollars using the same average foreign currency exchange rates for the conversion of revenues into U.S. dollars that we used to translate local currency revenues for the comparable reporting period of the prior year. The company then calculates the difference between the IFRS revenue and the constant currency revenue to yield the “constant currency impact” for the current period.  

The company’s management and board of directors use constant currency revenue growth to evaluate growth and generate future operating plans. The exclusion of the impact of exchange rate fluctuations provides comparability across reporting periods and reflects the effects of customer acquisition efforts and land-and-expand strategy. Accordingly, it believes that this non-IFRS measure provides useful information to investors and others in understanding and evaluating revenue growth in the same manner as the management and board of directors. However, this non-IFRS measure has limitations, particularly as the exchange rate effects that are eliminated could constitute a significant element of its revenue and could significantly impact performance and prospects. Because of these limitations, you should consider this non-IFRS measure alongside other financial performance measures, including revenue and revenue growth presented in accordance with IFRS and other IFRS results. 

The table below provides the reconciliation of the most comparable IFRS growth measures to the non-IFRS growth measures for the current period. 

About SOPHiA GENETICS 

SOPHiA GENETICS (Nasdaq: SOPH) is a cloud-native healthcare technology company on a mission to expand access to data-driven medicine by using AI to deliver world-class care to patients with cancer and rare disorders across the globe. It is the creator of SOPHiA DDM™, a platform that analyzes complex genomic and multimodal data and generates real-time, actionable insights for a broad global network of hospital, laboratory, and biopharma institutions. For more information, visit SOPHiAGENETICS.COM and connect with us on LinkedIn. 

Forward-Looking Statements 

This press release contains statements that constitute forward-looking statements. All statements other than statements of historical facts contained in this press release, including statements regarding SOPHiA GENETICS future results of operations and financial position, business strategy, products and technology, partnerships and collaborations, as well as plans and objectives of management for future operations, are forward-looking statements. Forward-looking statements are based on SOPHiA GENETICS’ management’s beliefs and assumptions and on information currently available to the company’s management. Such statements are subject to risks and uncertainties, and actual results may differ materially from those expressed or implied in the forward-looking statements due to various factors, including those described in the company’s filings with the U.S. Securities and Exchange Commission. No assurance can be given that such future results will be achieved. Such forward-looking statements contained in this press release speak only as of its date. We expressly disclaim any obligation or undertaking to update these forward-looking statements contained in this press release to reflect any change in the company’s expectations or any change in events, conditions, or circumstances on which such statements are based, unless required to do so by applicable law. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements. 

Investor and Media Contact:  

Kellen Sanger 

[email protected] 

[email protected] 

Boston, MA, and Rolle, Switzerland, February 10, 2026 – SOPHiA GENETICS (NASDAQ: SOPH), a global leader in AI-driven precision medicine, today announced the addition of two of the largest U.S. healthcare systems to its network.

The two new institutions, which collectively analyze millions of genetic samples annually, include one of the leading nonprofit, multi-region integrated healthcare systems in the U.S. and a top 10 U.S. health system laboratory. Together, these institutions will leverage the AI-native, cloud-based SOPHiA DDM^™ to analyze complex genomic data at scale.

By adopting SOPHiA DDM^™, the two institutions will initially launch genomic testing for up to 60,000 patients annually across the West Coast and Midwest, enabling faster diagnosis and more personalized care for individuals living with hereditary cancers and rare diseases.

Both health systems will utilize SOPHiA DDM™ for Enhanced Exome, an AI-driven analytics application that supports comprehensive full-exome analysis for over 20,000 genes while enabling the ability to dive deeper into clinically relevant regions. With these capabilities directly embedded into their laboratory workflows, the institutions aim to expedite testing turnaround times, streamline operational costs, and expand internal research and innovation initiatives.

John Carey, Managing Director, North America, SOPHiA GENETICS, said: “Partnering with two of the largest health systems in the U.S. underscores the growing need for AI-powered genomic solutions capable of addressing increasingly complex use cases that can scale without adding operational burden. Combining advanced bioinformatics, the collective knowledge of a global community, and streamlined workflows, our AI enables healthcare institutions to unlock deeper insights.”

Going forward, this collaboration positions both organizations with a scalable foundation to support future expansion of AI-driven precision medicine. Each year, these organizations serve a combined population of nearly one million cancer and rare disorder patients nationwide.

SOPHiA GENETICS continues to strengthen its presence in the United States while supporting leading healthcare institutions across some of the most complex areas of precision medicine. The expansion in the region reinforces the company’s mission to democratize data-driven medicine by equipping researchers and clinicians with AI-powered solutions that accelerate healthcare innovation and research.

For more information on SOPHiA GENETICS, visit SOPHiAGENETICS.com or connect on LinkedIn. 

The Company finishes 2025 with strong Q4 performance, expects 20-22% revenue growth in 2026, and promotes Ross Muken to CEO

BOSTON and ROLLE, Switzerland, Jan. 12, 2026 /PRNewswire/ -- SOPHiA GENETICS (Nasdaq: SOPH), a global leader in AI-driven precision medicine, today provided preliminary unaudited financial results for the fourth quarter and full year 2025, initiated its financial outlook for 2026, and announced an executive transition plan, including the promotion of Ross Muken to Chief Executive Officer (CEO), effective July 1, 2026, and the transition of co-Founder Jurgi Camblong to Executive Chairman.

Fourth Quarter 2025 Preliminary Unaudited Financial Results

• Revenue of at least $21 million, representing an increase of approximately 20% year-over-year
• Performed over 105,000 analyses on SOPHiA DDM™ in the fourth quarter, representing 16% year-over-year growth

Full Year 2025 Preliminary Unaudited Financial Results

• Revenue of approximately $77 million, representing an increase of approximately 18% year-over-year
• Performed over 391,000 analyses on SOPHiA DDM™ in 2025, a new company record

"2025 was a tremendous year for SOPHiA GENETICS as we reaccelerated revenue growth and materially exceeded our new business bookings target, setting the stage for robust future growth," said Jurgi Camblong, Chief Executive Officer of SOPHiA GENETICS. "Our strong performance in 2025 positions us well for continued growth in 2026 and beyond. Growth catalysts for the year ahead include our best-in-class Liquid Biopsy application MSK-ACCESS^® powered with SOPHiA DDM™, valuable opportunities in the U.S. market, and a reinvigorated BioPharma business. We look forward to continuing to demonstrate operating leverage in 2026 and have high confidence in a material improvement in our financial position."

Full Year 2026 Guidance

Based on information as of today, SOPHiA GENETICS is providing the following FY 2026 guidance:

• Full year revenue between $92 million and $94 million, representing approximately 20% to 22% year-over-year growth
• Adjusted EBITDA loss between $29 million and $32 million

Executive Transition Plan

SOPHiA GENETICS today announced the promotion of Ross Muken to Chief Executive Officer, effective July 1, 2026. Mr. Muken, who currently serves as President and has been a key executive at the company for five years, will succeed Dr. Jurgi Camblong, co-founder and CEO. Dr. Camblong will transition to Executive Chairman of the Board, subject to election at the company's Annual General Meeting in June 2026.

Throughout 2025, Dr. Camblong has focused on positioning SOPHiA GENETICS for its next phase of growth. As Executive Chairman, he will continue as a full-time executive, concentrating on strategic initiatives, technology innovation, and long-term strategic direction.

"These executive changes reflect the Board's and Dr. Camblong's long-term succession planning," said Dr. Tomer Berkovitz, SOPHiA GENETICS Board Member and Managing Partner at aMoon Fund. "Jurgi has built a remarkable and unique company that has pioneered the application of AI in precision medicine, and we look forward to continuing our work with him, Ross, and the broader leadership team to transform patient care."

Ross Muken joined SOPHiA GENETICS in February 2021, prior to the Company's initial public offering, as Chief Financial Officer (CFO). In March 2023, he expanded his responsibilities to serve as joint CFO and Chief Operating Officer (COO), leading the Company's go-to-market organization, including Clinical Sales, BioPharma Diagnostics Sales, Sales Support, Marketing, Customer Experience, and Operations. In May 2024, Mr. Muken was promoted to company President, overseeing SOPHiA GENETICS' global business operations. In this role, he has played a central role in transforming the commercial organization and sales processes, reaccelerating business growth, and strengthening overall commercial execution.

"The last 15 years have been an incredible journey, realizing our vision to democratize data-driven medicine across more than 70 countries and 800 healthcare institutions. Having worked closely with Ross for five years, I've seen firsthand his exceptional strategic capabilities and operational leadership. I am confident he is the right person to lead the company through its next phase of growth and significantly expand our global impact," said Jurgi Camblong, SOPHiA GENETICS co-Founder.

"Jurgi has built something truly remarkable over the past 15 years, a unique company and technology platform that stands apart in the industry," said Ross Muken. "When I joined in 2021, I immediately recognized this was a category-defining company applying AI and cloud computing at unprecedented scale. Over these five years, working alongside Jurgi has been extraordinary. I've gained deep insights into our customers' needs, our technology's capabilities, and the exceptional talent of our team. I'm deeply honored to succeed Jurgi as CEO and look forward to continuing our partnership as he transitions to Executive Chairman."

Kevin Puylaert, the company's current Managing Director of EMEA, is appointed Chief Sales Officer effective January 2026. Kevin has been with SOPHiA GENETICS for more than 10 years, during which he has held multiple senior leadership roles, and his contributions have been instrumental to the company's growth.

Important Note Regarding Preliminary Unaudited Financial Results

SOPHiA GENETICS has not completed preparation of its financial statements for the fourth quarter or full year of 2025. The estimates presented in this news release for the fourth quarter and year ended December 31, 2025 are preliminary and unaudited and are thus inherently uncertain and subject to change as we complete our financial results for the fourth quarter of 2025. SOPHiA GENETICS is in the process of completing its customary year-end close and review procedures as of and for the year ended December 31, 2025, and there can be no assurance that final results for this period will not differ from these estimates. During the course of the preparation of SOPHiA GENETICS' consolidated financial statements and related notes as of and for the year ended December 31, 2025, we may identify items that could cause final reported results to be materially different from the preliminary financial estimates presented herein.

SOPHiA GENETICS plans to report its complete fourth quarter and full year 2025 financial results during its first earnings call of 2026 currently scheduled for March 3, 2026.

Boston, MA and Houston, TX – January 7, 2026 – SOPHiA GENETICS (NASDAQ: SOPH), a global leader in AI-driven precision medicine, and The University of Texas MD Anderson Cancer Center today announced a strategic collaboration that unites SOPHiA GENETICS’ AI-powered analytics with MD Anderson’s clinical and scientific expertise to accelerate data-driven cancer care through new tools that can accurately analyze, interpret and translate diagnostic results into clinical practice.

As part of the collaboration, MD Anderson and SOPHiA GENETICS are launching a series of research and development programs and co-developing an advanced next-generation sequencing oncology test. Built on the advanced AI algorithms of the SOPHiA DDM™ Platform, the new co-developed test aims to translate complex multimodal data into actionable insights with greater speed and scale. MD Anderson researchers will tap SOPHiA GENETICS’ AI technologies to create bioinformatics pipelines that enable clinicians to rapidly interpret complex RNA-sequencing data to guide diagnosis and treatment for patients with cancer.

Donna Hansel, M.D., Ph.D., Division Head of Pathology and Laboratory Medicine at MD Anderson, said: “Cancer research has evolved rapidly, and we have more health data available than ever before. Our collaboration with SOPHiA GENETICS reflects how our lab is evolving and integrating advanced analytics and AI to better interpret complex molecular information. This collaboration will expand our ability to translate high-dimensional data into insights that can meaningfully advance research and precision oncology.”

In addition, MD Anderson and SOPHiA GENETICS will jointly launch a series of research and development programs to explore new ways to characterize tumor evolution in real time, to strengthen the reliability and reproducibility of complex genomic testing, and to enhance the ability to identify optimal clinical trials or research avenues for individual patients. This multi-layered program is designed to fuel next-generation scientific discovery, empowering clinicians and researchers with tools to better understand the dynamic nature of cancer. The collaborative work at MD Anderson will be led by Shashikant Kulkarni, Ph.D., deputy division head for Molecular Pathology, and J. Bryan, M.D., assistant professor, both in the Division of Pathology and Laboratory Medicine.

Philippe Menu, M.D., Ph.D., Chief Product Officer and Chief Medical Officer, SOPHiA GENETICS, said: “This collaboration with MD Anderson amplifies our shared ambition to push the boundaries of what is possible in cancer research. With SOPHiA DDM™ as a unifying analytical layer, we are enabling new discoveries, accelerating breakthroughs in precision oncology and, most importantly, enabling patients around the globe to benefit from these innovations by bringing leading technologies to all geographies quickly and at scale.”

For more information on SOPHiA GENETICS, visit SOPHiAGENETICS.com, or connect on LinkedIn.  

BOSTON, MA, November 11, 2025 – Complete Genomics, a leading innovator in genomic sequencing, today announced a collaboration with SOPHiA GENETICS (NASDAQ: SOPH), a global leader in AI-driven precision medicine, to launch and co-market MSK-ACCESS® and MSK-IMPACT® powered with SOPHiA DDM™ on Complete Genomics’ DNBSEQ-T1+ sequencing platform.  The companies aim to broaden access to precision oncology testing by offering the best-in-class liquid biopsy and solid tumor applications to customers globally. The announcement was made from the Association for Molecular Pathology (AMP) Annual Meeting in Boston.

The collaboration integrates SOPHiA GENETICS’ advanced, AI-powered applications MSK-IMPACT® and MSK-ACCESS® powered by SOPHiA DDM™, developed in collaboration with Memorial Sloan Kettering Cancer Center (MSK), with Complete Genomics’ newly launched DNBSEQ-T1+ sequencing platform. Together, Complete Genomics and SOPHiA GENETICS will provide an integrated, sample-to-report workflow for laboratories, marking a significant expansion of their partnership into the precision oncology research market.

“Pairing MSK-IMPACT® and MSK-ACCESS® powered with SOPHiA DDM™ with our DNBSEQ-T1+ platform creates a powerful and accessible solution for laboratories looking to scale high-quality cancer genomic profiling,” said Rob Tarbox, vice president of product and marketing at Complete Genomics. “By combining MSK’s rigorously validated assays, SOPHiA GENETICS’ robust analytics, and our sequencing technology, we are enabling decentralized labs to deliver faster, more accurate, and more affordable insights to clinicians and researchers.”

“This collaboration underscores SOPHiA GENETICS’ commitment to broadening access to data-driven medicine,” said Ross Muken, President,SOPHiA GENETICS. “Partnering with Complete Genomics to streamline use of MSK-IMPACT® and MSK-ACCESS® powered with SOPHiA DDM™ on the DNBSEQ-T1+ platform enables more laboratories around the world to adopt precision oncology through scalable, end-to-end genomic solutions.”

The DNBSEQ-T1+, powered by proprietary DNBSEQ technology, delivers Q40-level accuracy, optimized throughput from 500 million to 2 billion reads per flow cell. Each flow cell is able to be run independently, with a 24-hour paired-end 150bp run time, offering laboratories a cost-effective and highly flexible sequencing solution. At maximum throughput, each T1+ flow cell can run up to  60 tumor-normal sample pairs for tissue, up to 16 tumor-normal sample pairs for liquid biopsy.

SOPHiA DDM™ is a technology-agnostic analytics platform that leverages AI to compute, standardize, and analyze healthcare data. Joint evaluation of MSK-IMPACT® and MSK-ACCESS® on the DNBSEQ-T1+ platform demonstrated highly concordant variant calls and allele frequencies compared with equivalent sequencing systems, while achieving lower background noise, reduced turnaround time, and seamless compatibility with existing SOPHiA DDM™ workflows.

This new offering provides clinical laboratories, cancer centers, and drug developers with a high-performance, cost-efficient path to implementing comprehensive genomic profiling for precision oncology research.

To learn more, visit the Complete Genomics Booth 1210 or SOPHiA GENETICS Booth 921 at AMP from November 11–15, 2025 or visit www.CompleteGenomics.com and  www.SOPHiAGENETICS.com.

About Complete Genomics

Complete Genomics is a pioneering life sciences company that provides novel, complete sequencing solutions including sample/library preparation, lab automation, sequencing, and data analysis. The sequencing portfolio offers a full lineup of sequencers ranging from low, medium, and high throughput capacities, all powered by its proprietary DNBSEQ technology. More than 10,900 publications are based on DNBSEQ technology across a wide array of applications. To learn more, visit www.completegenomics.com.

* For Research Use Only. Not for use in diagnostic procedures.

Boston, MA and San Diego, CA, November 11, 2025 – SOPHiA GENETICS (NASDAQ: SOPH), a global leader in AI-driven precision medicine, and Element Biosciences, Inc., a biology company transforming the pace and accessibility of scientific discovery, today announced at the Association for Molecular Pathology (AMP) Annual Meeting a partnership that unites sequencing and AI analytics to streamline genomic workflows and accelerate the research supporting precision medicine.

This collaboration integrates SOPHiA GENETICS’ AI-powered analytics platform, SOPHiA DDM™, with Element’s AVITI24™ 5D multiomic and AVITI™ sequencing systems to deliver a seamless, end-to-end workflow for next-generation sequencing (NGS). Together, the technologies will provide speed, scalability, and flexibility, enabling clinical researchers to turn NGS data into actionable insights within a single streamlined process. AVITI and AVITI24 users will also gain access to the full suite of SOPHiA DDM™ applications in oncology and rare disease, expanding the analytical power of their sequencing workflows.

Professor Hagay Sobol, Head of the Molecular Oncogenetics Laboratory at the Institut Paoli-Calmettes (IPC), said: “We believe that combining the Element AVITI system with the SOPHiA DDM™ Platform has the potential to transform the way our lab approaches genomic testing by seamlessly delivering highly accurate results. We expect this collaboration that pairs SOPHiA GENETICS’ powerful analytics with Element’s sequencing performance will be able to deliver the consistency and scalability needed for research that helps bring precision medicine to more patients, faster.” IPC is a comprehensive cancer center in Marseille, France, specializing in cancer research, treatment, and teaching.

Jurgi Camblong, CEO and Co-Founder of SOPHiA GENETICS, said: “Integrating our universal platform with leading sequencing technologies such as the Element AVITI system allows healthcare organizations, regardless of size or geography, to adopt innovative, AI-driven technologies while keeping genomic research local. This partnership aligns with our shared goals of democratizing access to research that supports precision medicine globally, bringing data-driven decisions closer to home, and extending the reach of our respective technologies.”

Molly He, CEO and Co-Founder of Element Biosciences, said: “Pairing Element’s cutting-edge AVITI and AVITI24 systems with SOPHiA GENETICS’ powerful AI analytics is a game-changer for the genomics community. This collaboration doesn’t just streamline workflows - it redefines what’s possible in sequencing, delivering richer insights, faster results and unprecedented accessibility. Together, we’re breaking down barriers to enable the future of precision medicine and empower every lab, everywhere, to do more with their data.”

About the technology

SOPHiA DDM™ is a technology-agnostic analytics platform that leverages AI to compute, standardize and analyze healthcare data. Since its inception, SOPHiA GENETICS has been committed to ensuring compatibility across all technologies. Through this partnership, laboratories can process datasets of any size, retain full control of their data, and scale efficiently as precision medicine adoption accelerates worldwide.

Element Biosciences’ AVITI24 5D Multiomic and AVITI next generation sequencing systems are designed to make high-performance genomics accessible to all. With its combination of accuracy, flexibility, and cost efficiency, Element empowers laboratories to scale with confidence and accelerate the researching driving precision medicine worldwide.

To learn more about the partnership or SOPHiA GENETICS, connect with the team at booth 921 at AMP in Boston, Massachusetts from November 11 – 15 or visit SOPHiAGENETICS.com.

ROLLE AND TOKYO, October 16, 2025 – A.D.A.M. Innovations, Japan's leading private genetic testing company, and SOPHiA GENETICS (Nasdaq: SOPH), an AI technology company pioneering data-driven medicine, today announced at ESMO a strategic agreement to bring cutting-edge liquid biopsy genomic testing to the Japanese population. The companies will also partner to commercialize a liquid biopsy companion diagnostic aimed at advancing personalized and precision cancer care in Japan.

As a market leader for genetic testing in Japan with a high-throughput laboratory located in central Tokyo, A.D.A.M. Innovations has served the Japanese population for over 20 years and completed over 2.8 million genomic tests to-date. A.D.A.M. Innovations will continue its legacy of bringing global innovations to Japan by adopting the AI-powered SOPHiA DDM™ Platform to advance personalized cancer testing across the country.

The partnership will initially focus on launching the liquid biopsy application, MSK-ACCESS® powered with SOPHiA DDM^TM. This innovative liquid biopsy test is designed to detect actionable genomic alterations from a single blood draw, leveraging state-of-the-art AI to analyze circulating tumor DNA (ctDNA) in a minimally invasive manner. The test utilizes a matched tumor-normal approach which improves accuracy and avoids false positives. By launching the test locally and analyzing samples in-house, A.D.A.M. Innovations will expedite testing turnaround times, reduce costs to patients, and advance local cancer research.

As part of the partnership, the companies also aim to develop a liquid biopsy companion diagnostic (CDx) test in Japan. By developing the application into a CDx, more patients can gain access to the benefits of the high-quality tumor profiling test, advancing personalized healthcare at scale. The offering will also provide pharmaceutical partners with a powerful new tool to accelerate drug development and market access in Japan. The companies will collaborate across all steps of the development process, with A.D.A.M. Innovations leveraging its deep clinical and regulatory expertise to support regulatory submissions in Japan.

“Making precision oncology more accessible to patients in Japan is a significant milestone,” said Ross Muken, President, SOPHiA GENETICS. “By combining A.D.A.M. Innovations’ strong clinical expertise and local presence with the global reach of the SOPHiA DDM™ Platform, we can drive the nationwide adoption of data-driven medicine, advancing both clinical research and the delivery of personalized oncology care.”

“For over two decades, we have supported academic, research and medical institutions with advanced clinical genomic testing,” commented Michel Mommejat, President of A.D.A.M. Innovations. “Through our partnership with SOPHiA GENETICS and its AI-driven platform, we are taking a major step forward in accelerating precision oncology across Japan. Testing locally enables faster turnaround times, reduces costs, enhances patient care, and supports global CDx deployments.”

The collaboration was formally announced from the European Society for Medical Oncology (ESMO) Congress 2025 in Berlin. The announcement underscores both companies’ shared commitment to advancing data-driven and liquid biopsy-based solutions for cancer care in Japan. Learn more by connecting with SOPHiA GENETICS and A.D.A.M. Innovations at ESMO booth #2039 from October 17-21, 2025.

For more information on SOPHiA GENETICS, visit SOPHiAGENETICS.COM, or connect on LinkedIn.

For more information on A.D.A.M. Innovations, visit ADAM-INNOVATIONS.COM or connect on LinkedIn.

Boston, MA and Rolle, Switzerland – October 16, 2025 — SOPHiA GENETICS (Nasdaq: SOPH), a leader in AI-driven precision medicine, today announced the launch of SOPHiA DDM™ Digital Twins, a breakthrough research technology that creates dynamic, virtual representations of individual patients to simulate potential outcomes and help oncologists make better treatment decisions.  

SOPHiA DDM™ Digital Twins uses each patient’s unique clinical, biological, imaging, and genomic data to generate a computational replica of the patient and their individual disease. Oncologists can use the virtual replica of the patient, or Digital Twin, to simulate treatment responses, disease trajectories, and survival outcomes in real time, and to explore potential treatment strategies virtually before making decisions at the bedside.

“Digital twin technology enables integrative visualization of multimodal oncologic data, revealing latent correlations across modalities. By simulating disease trajectories and therapeutic responses within a virtual environment, Digital Twins offer a framework for in silico experimentation, supporting anticipatory and individualized clinical decision-making,” said Dr. Pierre Heudel, Medical Oncologist, Centre Léon Bérard.

“This breakthrough technology represents an important step forward in helping clinicians make more informed decisions for complex cancers,” said Dr. Clara Montagut, Head of Gastrointestinal Cancer, Hospital del Mar. “Having a digital model that can simulate potential outcomes before treatment has the potential to be transformative in how we deliver future care.”

Digital Twins leverages the collective intelligence of the SOPHiA GENETICS community and a robust, multimodal, longitudinal dataset to simulate potential therapy response. The tool equips clinicians with insights derived from a broad network of global patient cases by breaking down institutional and geographic barriers and enabling clinicians to tap into a global intelligence to enhance decision making.

“Building on advances from preclinical and clinical research, digital-twin technology offers new avenues to enhance the diagnosis and management of complex diseases, including cancer. SOPHiA DDM™ Digital Twins provides clinicians and researchers with a robust, data-driven framework for hypothesis testing and may represent a meaningful step toward broader implementation of precision medicine,” noted Dr. Ernest Nadal, Director of Research and Innovation, Catalan Institute of Oncology.

Dr. Mariano Provencio Pulla, Head of the Medical Oncology Department, Puerta de Hierro University Hospital, added, “The Digital Twins concept developed by SOPHiA GENETICS is really a breakthrough in oncology. We absolutely need this approach to take full advantage of major progress that has been made in clinical care in recent years, especially in the context of pre-surgical immunotherapy for patients with non-small cell lung cancer eligible for surgery. I truly believe that it is the future of data-driven medicine.”

Powered by state-of-the-art artificial intelligence, SOPHiA DDM™ Digital Twins continuously evolves as new data becomes available, strengthening accuracy and research capabilities over time. The tool also generates synthetic data that reflects real-world disease patterns, enabling researchers to explore additional therapeutic paths and model potential outcomes before committing to a treatment strategy.

“Cancer is constantly evolving, and static snapshots are no longer enough,” said Jurgi Camblong, Ph.D., Co-Founder & CEO, SOPHiA GENETICS. “With SOPHiA DDM™ Digital Twins, we can create advanced AI models based on our broad patient network, accelerating research, sharpening clinical decisions, and turning today’s insights into tomorrow’s breakthroughs. This reflects our ambition to make data-driven medicine the global standard of care.”

SOPHiA DDM™ Digital Twins brings key features that could, in the future, reshape precision oncology:

• Personalized Treatment Insights: Help oncologists match patients to the most effective treatment strategies based on simulated outcomes, including ability to explore relevant clinical trials.
• Toxicity and Cost Avoidance: Provide insights to help physicians reduce patient exposure to ineffective therapies that drive unnecessary side effects and expenses.
• Global Knowledge, Local Impact: Leverage one of the world’s most robust, de-identified multimodal cancer datasets to help oncologists make better decisions.

This launch marks a new era in precision oncology, one where technology empowers physicians to move beyond retrospective evidence and toward forward-looking, AI-powered decision support tailored to each patient. Digital Twins is launching on the SOPHiA DDM^TM Platform for lung cancer, with more cancer types available in the coming months.

To learn more about Digital Twins or SOPHiA GENETICS, connect with the team at ESMO in Berlin, Germany from October 17 – 21 or visit SOPHiAGENETICS.COM.

SALT LAKE CITY AND BOSTON, MA - September 23, 2025 – Myriad Genetics (Nasdaq: MYGN), a leader in molecular diagnostic testing and precision medicine, and SOPHiA GENETICS (Nasdaq: SOPH), an AI technology company transforming precision medicine, announced a strategic collaboration to develop and provide pharmaceutical companies with an innovative global liquid biopsy companion diagnostic (CDx) test. This partnership will leverage Myriad’s advanced laboratory capabilities in the U.S. to support global testing for clinical trials and SOPHiA GENETICS’ broad, decentralized network of more than 800 connected institutions in more than 70 countries for global test deployment.

“Serving patients and healthcare providers along the cancer care continuum is a strategic focus for Myriad Genetics,” said Sam Raha, President and CEO, Myriad Genetics. "We expect this collaboration with SOPHiA GENETICS to support the development and global commercialization of comprehensive CDx solutions for our BioPharma partners with the potential to positively impact patient lives, add an important product offering to the Myriad menu and support the growth of our CDx programs."

SOPHiA GENETICS and Myriad will initially focus on the liquid biopsy application, MSK-ACCESS® powered with SOPHiA DDM™. Developed in collaboration with Memorial Sloan Kettering Cancer Center, MSK-ACCESS® powered with SOPHiA DDM™ is an innovative liquid biopsy test that detects actionable genomic alterations from a single blood draw using proprietary, state-of-the-art algorithms which analyze circulating tumor DNA (ctDNA). By developing the application into a CDx, more patients can gain access to the benefits of this high-quality tumor profiling test, advancing personalized healthcare at scale.

Myriad will pursue regulatory submissions in the U.S., and SOPHiA GENETICS will manage regulatory submissions outside of the U.S. Both companies will collaborate across development activities. This innovative, hybrid approach is expected to provide pharmaceutical partners with access to key regulated markets globally.

“This collaboration represents a pivotal moment for the industry,” said Jurgi Camblong, Co-founder and CEO of SOPHiA GENETICS. “By combining the complementary strengths of a specialty lab leader and a global testing network, we are not only expanding access to innovative oncology testing but also laying the foundation for a new hybrid model in companion diagnostics. This collaboration will allow us to serve both clinical and pharmaceutical partners better, while accelerating the adoption of liquid biopsy solutions across key markets.”

SOPHiA GENETICS and Myriad will participate in a panel discussion at the World CB and CDx Summit in Boston and provide additional details on the collaboration.

BOSTON, MA - September 22, 2025 – SOPHiA GENETICS (Nasdaq: SOPH), an AI technology company transforming precision medicine, today announced an expansion of its collaboration with AstraZeneca (LSE/STO/Nasdaq: AZN) from the World CB & CDx Summit in Boston. The companies aim to improve the diagnosis and treatment of breast and prostate cancer by developing an optimized next generation sequencing (NGS) solution that leverages SOPHiA GENETICS’s AI algorithms to detect genetic mutations in the PIK3CA/AKT1/PTEN pathway.

The PIK3CA/AKT1/PTEN pathway is a key molecular signaling network that regulates how cells grow and survive, and its disruption is linked to the development of many cancers, including breast and prostate cancer. The PTEN gene, when altered, can contribute to cancer development and resistance to treatment. As part of this collaboration, the companies have developed an optimized NGS solution that deploys AI agents to analyze and detect genomic mutations across the full PTEN gene. A prototype of the enhanced solution has already demonstrated improved sensitivity in its ability to detect complex mutations across the pathway.

As part of the agreement, SOPHiA GENETICS will roll out a Privileged Access Program to selected clinical laboratories specializing in breast and prostate cancer research to validate sensitivity in a real-world setting, with broader commercial availability expected in 2026, alongside a multi-center real-world evidence study to further test its effectiveness. SOPHiA GENETICS’s global network will also help drive adoption of advanced PIK3CA/AKT1/PTEN testing in both tissue and liquid biopsy to expand patient access to precision therapies.

“Each day brings new insights that transform our understanding of cancer. Partnering with innovative biopharma leaders like AstraZeneca allows us to translate these discoveries into action for breast and prostate cancer patients worldwide, representing another step forward in our mission to democratize data-driven medicine.” said Ross Muken, President, SOPHiA GENETICS.

The expanded partnership highlights the shared commitment of SOPHiA GENETICS and AstraZeneca to drive innovation in precision oncology and to ensure that patients across the globe can benefit from advanced genomic testing and targeted treatments. To learn more, connect with SOPHiA GENETICS at the World CB & CDx Summit in Boston, MA from September 22-25, 2025

For more information on SOPHiA GENETICS, visit SOPHiAGENETICS.COM, or connect on LinkedIn.