OncoPortal™ Knowledge Base

Advancing interpretation of somatic variants
OncoPortal™ Knowledge Base supports fast and accurate interpretation of clinically relevant genomic variants and biomarkers by aggregating expertly curated, clinically relevant data from multiple sources into one place.

Putting genomic biomarkers into the relevant clinical context

Match tumor molecular profiles with biologically actionable information on diagnosis, prognosis, treatments, and clinical trials via a single, streamlined knowledgebase that compiles clinical insights for confident decision-making.
Maximize efficiency
OncoPortal™ Knowledge Base is fully integrated into the streamlined SOPHiA DDM™ workflow, reducing time per case.
Reveal actionable insights
Comprehensive information from expertly curated content and clinical guidelines place genomic biomarkers into the relevant clinical context.
Customize your analysis

The user-friendly interface provides at-a-glance visualization of bespoke, clinically-relevant insights for streamlined variant interpretation.

Place genomic biomarkers into the relevant clinical context

Actionable biomarker identification
Molecular profiles of co-occurring biomarkers are compared, so you can consider the compound impact of multiple actionable tumor alterations on therapy, diagnosis, prognosis, and cancer susceptibility.
Variant tier classification
Variants are assigned tiers (I-IV) based on the AMP/ASCO/CAP standards and guidelines for the interpretation and reporting of somatic variants.
Rich interpretive information
Recommendations from guidelines (NCCN/ESMO) and regulatory approvals (FDA/EMA/TGA/ANVISA) are highlighted, supported by scientific literature.
Clinical trial matching

>13,000 ongoing clinical trials around the globe are matched with detected variants and individual parameters such as country and disease.

Comprehensive reporting

Key variant information, actionable insights, and personalized annotations and interpretations can be added to your report in just a few clicks.

Sample-to-report workflows

The OncoPortal™ Knowledge Base launches with a single click, automatically matching molecular profiles to relevant clinical associations. Selected clinical evidence can be seamlessly added to your report for fast, simplified interpretation.

Download Sample Report

Up-to-date knowledge base

The OncoPortal™ oncology knowledgebase is curated by experts to compile all relevant clinical insights in one place. It is powered by the Genomenon Cancer Knowledgebase (CKB) and is manually expanded with curations and user contributions.

  • >1,900 genes
  • >45,000 variants
  • >13,000 clinical trials
  • >4,000 targeted therapies

SOPHiA GENETICS products are for Research Use Only and not for use in diagnostic procedures unless specified otherwise.

SOPHiA DDM™ Dx Hereditary Cancer Solution, SOPHiA DDM™ Dx RNAtarget Oncology Solution and SOPHiA DDM™ Dx Homologous Recombination Deficiency Solution are available as CE-IVD products for In Vitro Diagnostic Use in the European Economic Area (EEA), the United Kingdom and Switzerland. SOPHiA DDM™ Dx Myeloid Solution and SOPHiA DDM™ Dx Solid Tumor Solution are available as CE-IVD products for In Vitro Diagnostic Use in the EEA, the United Kingdom, Switzerland, and Israel. Information about products that may or may not be available in different countries and if applicable, may or may not have received approval or market clearance by a governmental regulatory body for different indications for use. Please contact us at [email protected] to obtain the appropriate product information for your country of residence.

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