In this episode, Dr. Jurgi Camblong travels to the University of Oxford to meet Professor Nicholas Proudfoot, one of the true pioneers of molecular biology.
For more than five decades, Nick has helped decode life itself, revealing how genes are turned on and off, how RNA carries meaning beyond proteins, and how curiosity can drive discoveries that last a lifetime.
Together, they revisit the early days of modern biology - a time before PCR or cloning - and trace how one generation of scientists transformed trial and error into the precision science we know today.
From the discovery of the AAUAAA “full stop” that signals where genes end, to showing how DNA loops connect beginnings and endings, this is the story of how the foundations of modern genetics were built, one question at a time.
You’ll hear about:
Recorded in Oxford, this episode is a love letter to discovery - and to the mentors who remind us that innovation starts with a simple question: why?
"All great discoveries begin with curiosity. If we stop funding curiosity-driven science, we stop funding the foundation of tomorrow’s medicine."



SOPHiA GENETICS products are for Research Use Only and not for use in diagnostic procedures unless specified otherwise.
SOPHiA DDM™ Dx Hereditary Cancer Solution, SOPHiA DDM™ Dx RNAtarget Oncology Solution and SOPHiA DDM™ Dx Homologous Recombination Deficiency Solution are available as CE-IVD products for In Vitro Diagnostic Use in the European Economic Area (EEA), the United Kingdom and Switzerland. SOPHiA DDM™ Dx Myeloid Solution and SOPHiA DDM™ Dx Solid Tumor Solution are available as CE-IVD products for In Vitro Diagnostic Use in the EEA, the United Kingdom, Switzerland, and Israel. Information about products that may or may not be available in different countries and if applicable, may or may not have received approval or market clearance by a governmental regulatory body for different indications for use. Please contact us to obtain the appropriate product information for your country of residence.
All third-party trademarks listed by SOPHiA GENETICS remain the property of their respective owners. Unless specifically identified as such, SOPHiA GENETICS’ use of third-party trademarks does not indicate any relationship, sponsorship, or endorsement between SOPHiA GENETICS and the owners of these trademarks. Any references by SOPHiA GENETICS to third-party trademarks is to identify the corresponding third-party goods and/or services and shall be considered nominative fair use under the trademark law.