SOPHiA DDM™ for
Leveraging our extensive experience and knowledge in genomics, we built the SOPHiA GENETICS SARS-CoV-2 analytical solutions to enable a rapid and precise identification of circulating and emerging variants.
The combination of the SOPHiA DDM™ platform with the amplicon-based Paragon Genomics SARS-CoV-2 Panels offers coverage of the whole viral genome and sensitive variant detection through a streamlined, end-to-end workflow (from sample to surveillance report). The resulting solutions accelerate surveillance and evolution studies of SARS-CoV-2.
- Ultra-sensitive and fast SARS-CoV-2 whole genome analysis with tailored quality assessment
- Optimized identification and filtering for current and emerging variants
- Integrated access to public databases and secure knowledge sharing in peer networks
- SARS-CoV-2 Surveillance Report for real-time reporting of SARS-CoV-2 data
Generate high-quality viral genome data
The Paragon Genomics highly multiplexed target enrichment panels, CleanPlex® SARS-CoV-2 and SARS-CoV-2 FLEX, generate a sequencing-ready library in just 5.5 hours. Both solutions generate high-quality NGS libraries to reach 99% coverage of the viral genome for a more robust and confident variant calling, even as the virus mutates. In fact, the SARS-CoV-2 FLEX panel includes degenerate primers and additional internal library preparation control for consistent coverage to withstand mutations and more confident negative calls.
|SARS-CoV-2 Detection & Full Genome Coverage||+++||+++|
|Surveillance and Monitoring||++||+++|
|Human RNA Control||✓|
|New Variant Research||+||++|
|Spike in Optimization||✓|
+ = Good confidence, ++ = More sensitive/robust, +++ = Top performance
All versions can deliver reliable and robust performance for varying sequencing strategies.
Identify new and emerging variants with confidence
SOPHiA GENETICS has developed a fast, highly sensitive and analytically accurate detection workflow to surveil circulating, emerging SARS-CoV-2 variants at a global scale. The overall clade distribution in the SOPHiA DDM™ platform is similar to that of global datasets that require manual upload and analyses. With the SOPHiA DDM™ platform, data quality is controlled and analyses can be automated, and data screened in real time.
Real-time reporting of SARS-CoV-2 data with our SARS-CoV-2 Surveillance Report
The SOPHiA DDM™ platform offers at-a-glance reporting to help streamline the interpretation process of variants of concern (VOC), including valuable insights such as:
- Lineages associated with spike mutations
- Variant classification (VOC, VOI/VUI, VOHC, Monitoring) consistent with WHO/CDC and Public Health England
- Real-time tracking of known circulating variants by geography
- Hotspot identification by variant
- Key spike protein mutational monitoring
- New mutation and new mutation combination spotlights
- Insights enhanced with published scholarly data
Find Out More
End-to-end workflow to boost laboratory efficiency and enable retrospective analyses
Discover how the University Hospital of Sassari adopted SOPHiA DDM™ for SARS-CoV-2 to analyze thousands of COVID-19 samples and maintain public health surveillance.
Mutational hotspot in the SARS-CoV-2 Spike protein N-terminal domain conferring immune escape potential
Learn about a reported mutational hotspot from our researchers: a striking increase in the frequency of recruitment of diverse substitutions at a critical residue, W152, positioned in the N-terminal domain (NTD) of the Spike protein.
Recommendations for accurate genotyping of SARS-CoV-2 using amplicon-based sequencing of clinical samples
Read what our team, in collaboration with international centers, developed and published – in-line with WHO guidance – for the accurate genotyping of SARS-CoV-2.
SOPHiA GENETICS has demonstrated a proof of concept for real-time global variant surveillance of spike protein mutations through the SOPHiA GENETICS community secured peer-network and compared findings to the GISAID timeline.
A straightforward molecular strategy to retrospectively investigate the spread of SARS-CoV-2 VOC202012/01 B.1.1.7 variant
First reported cases of SARS-CoV-2 sub-lineage B.1.617.2 in Brazil: an outbreak in a ship and alert for spread