Is it possible to detect genomic (structural) rearrangements with paired-end Amplicon-based data?

The SOPHiA DDM™ Platform does not use paired-end information through Amplicon-based technology to detect structural rearrangements: genomic rearrangements cannot be detected. If a genomic rearrangement occurs in or adjacent to some amplicons, they will likely not amplify correctly. Thus, there would be no useable data.